Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2

Rheumatoid arthritis patients can be prescribed a combination of immunosuppressive drug leflunomide (LEF) and the antiviral drug acyclovir to reduce the high risk of infection. Acyclovir is a substrate of organic anion transporter (OAT) 1/3 and multidrug resistance-associated protein (MRP) 2. Consid...

Descripción completa

Detalles Bibliográficos
Autores principales: Liao, Xiao-ying, Deng, Qiang-qiang, Han, Li, Wu, Zhi-tao, Peng, Zhao-liang, Xie, Yuan, Wang, Guang-ji, Aa, Ji-ye, Pan, Guo-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470779/
https://www.ncbi.nlm.nih.gov/pubmed/31341258
http://dx.doi.org/10.1038/s41401-019-0283-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470779/
https://www.ncbi.nlm.nih.gov/pubmed/31341258
http://dx.doi.org/10.1038/s41401-019-0283-z

Ejemplares similares