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Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain

Paclitaxel-induced neuropathic pain (PINP) is refractory to currently used analgesics. Previous studies show a pivotal role of oxidative stress in PINP. Because the nuclear factor erythroid-2-related factor 2 (Nrf2) has been considered as the critical regulator of endogenous antioxidant defense, we...

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Detalles Bibliográficos
Autores principales: Zhou, Ya-qun, Liu, Dai-qiang, Chen, Shu-ping, Chen, Nan, Sun, Jia, Wang, Xiao-mei, Cao, Fei, Tian, Yu-ke, Ye, Da-wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470811/
https://www.ncbi.nlm.nih.gov/pubmed/32203087
http://dx.doi.org/10.1038/s41401-020-0394-6