Chemical and structural investigation of the paroxetine-human serotonin transporter complex

Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Structural and biochemical studies aiming to understand binding of small-molecules to conformationally dynamic transporters like SERT often require thermostabilizing mutations and antibodies to stabilize a spec...

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Detalles Bibliográficos
Autores principales: Coleman, Jonathan A, Navratna, Vikas, Antermite, Daniele, Yang, Dongxue, Bull, James A, Gouaux, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470834/
https://www.ncbi.nlm.nih.gov/pubmed/32618269
http://dx.doi.org/10.7554/eLife.56427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470834/
https://www.ncbi.nlm.nih.gov/pubmed/32618269
http://dx.doi.org/10.7554/eLife.56427

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