Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism

We have recently developed an enzyme-directed immunostimulant (EDI) prodrug motif, which is metabolized to active immunostimulant by cancer cells and, following drug efflux, activates nearby immune cells, resulting in immunogenicity. In this study, we synthesized several EDI prodrugs featuring an im...

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Detalles Bibliográficos
Autores principales: Ryan, Austin T, Pulukuri, Anunay J, Davaritouchaee, Maryam, Abbasi, Armina, Hendricksen, Aaron T, Opp, Larissa K, Burt, Anthony J, Nielsen, Amy E, Mancini, Rock J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470892/
https://www.ncbi.nlm.nih.gov/pubmed/32451412
http://dx.doi.org/10.1038/s41401-020-0432-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470892/
https://www.ncbi.nlm.nih.gov/pubmed/32451412
http://dx.doi.org/10.1038/s41401-020-0432-4

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