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Detection of base analogs incorporated during DNA replication by nanopore sequencing

DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no single method can identify the location, direction and speed of replication forks with high resolution. Mammalian cells have the ability to incorporate thymidine analogs along with the natural A, T, G and C base...

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Detalles Bibliográficos
Autores principales: Georgieva, Daniela, Liu, Qian, Wang, Kai, Egli, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470954/
https://www.ncbi.nlm.nih.gov/pubmed/32710620
http://dx.doi.org/10.1093/nar/gkaa517