RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes

Eukaryotic cellular mRNAs possess a 5′ cap structure (m(7)GpppN) which plays a critical role in translation initiation mediated by eukaryotic initiation factor (eIF) 4F. The heterotrimeric eIF4F complex possesses several activities imparted by its subunits that include cap recognition (by eIF4E), RN...

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Detalles Bibliográficos
Autores principales: Robert, Francis, Cencic, Regina, Cai, Renying, Schmeing, T Martin, Pelletier, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470955/
https://www.ncbi.nlm.nih.gov/pubmed/32749456
http://dx.doi.org/10.1093/nar/gkaa646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470955/
https://www.ncbi.nlm.nih.gov/pubmed/32749456
http://dx.doi.org/10.1093/nar/gkaa646

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