The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer

The IGF2 mRNA-binding protein 1 (IGF2BP1) is a non-catalytic post-transcriptional enhancer of tumor growth upregulated and associated with adverse prognosis in solid cancers. However, conserved effector pathway(s) and the feasibility of targeting IGF2BP1 in cancer remained elusive. We reveal that IG...

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Detalles Bibliográficos
Autores principales: Müller, Simon, Bley, Nadine, Busch, Bianca, Glaß, Markus, Lederer, Marcell, Misiak, Claudia, Fuchs, Tommy, Wedler, Alice, Haase, Jacob, Bertoldo, Jean Borges, Michl, Patrick, Hüttelmaier, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470957/
https://www.ncbi.nlm.nih.gov/pubmed/32761127
http://dx.doi.org/10.1093/nar/gkaa653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470957/
https://www.ncbi.nlm.nih.gov/pubmed/32761127
http://dx.doi.org/10.1093/nar/gkaa653

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