Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

The glucocorticoid receptor is an important immunosuppressive drug target and metabolic regulator that acts as a ligand-gated transcription factor. Generally, GR’s anti-inflammatory effects are attributed to the silencing of inflammatory genes, while its adverse effects are ascribed to the upregulat...

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Detalles Bibliográficos
Autores principales: Escoter-Torres, Laura, Greulich, Franziska, Quagliarini, Fabiana, Wierer, Michael, Uhlenhaut, Nina Henriette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470971/
https://www.ncbi.nlm.nih.gov/pubmed/32619221
http://dx.doi.org/10.1093/nar/gkaa565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470971/
https://www.ncbi.nlm.nih.gov/pubmed/32619221
http://dx.doi.org/10.1093/nar/gkaa565

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