Cargando…

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

The glucocorticoid receptor is an important immunosuppressive drug target and metabolic regulator that acts as a ligand-gated transcription factor. Generally, GR’s anti-inflammatory effects are attributed to the silencing of inflammatory genes, while its adverse effects are ascribed to the upregulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Escoter-Torres, Laura, Greulich, Franziska, Quagliarini, Fabiana, Wierer, Michael, Uhlenhaut, Nina Henriette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470971/ https://www.ncbi.nlm.nih.gov/pubmed/32619221 http://dx.doi.org/10.1093/nar/gkaa565

Ejemplares similares

DNA residence time is a regulatory factor of transcription repression
por: Clauß, Karen, et al.
Publicado: (2017)

Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements
por: Telorac, Jonas, et al.
Publicado: (2016)

Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites
por: Kulik, Marina, et al.
Publicado: (2021)

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites
por: Paakinaho, Ville, et al.
Publicado: (2021)

SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor
por: Paakinaho, Ville, et al.
Publicado: (2014)

Repressor activity of the RpoS/σ(S)-dependent RNA polymerase requires DNA binding
por: Lévi-Meyrueis, Corinne, et al.
Publicado: (2015)

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation
por: Love, Michael I., et al.
Publicado: (2017)

Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression
por: Portuguez, Avital Sarusi, et al.
Publicado: (2022)

Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1
por: Lin, Jianhuang, et al.
Publicado: (2017)

Pax7 pioneer factor action requires both paired and homeo DNA binding domains
por: Pelletier, Audrey, et al.
Publicado: (2021)

LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage
por: Stanulović, Vesna S., et al.
Publicado: (2017)

The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
por: Fauth, Torsten, et al.
Publicado: (2010)

GCNA is a histone binding protein required for spermatogonial stem cell maintenance
por: Ribeiro, Jonathan, et al.
Publicado: (2023)

Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress
por: Mira, Nuno P., et al.
Publicado: (2011)

The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences
por: Ren, Jianke, et al.
Publicado: (2015)

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity
por: Bollmann, Franziska, et al.
Publicado: (2014)

Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein
por: Tabib-Salazar, Aline, et al.
Publicado: (2017)

Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein
por: Koster, Maria J. E., et al.
Publicado: (2014)

LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation
por: Anan, Kotaro, et al.
Publicado: (2018)

Conventional and pioneer modes of glucocorticoid receptor interaction with enhancer chromatin in vivo
por: Johnson, Thomas A, et al.
Publicado: (2018)

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation
por: Stolz, Paul, et al.
Publicado: (2022)

The docking domain of histone H2A is required for H1 binding and RSC-mediated nucleosome remodeling
por: Shukla, Manu Shubhdarshan, et al.
Publicado: (2011)

Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses
por: Bolt, Michael J., et al.
Publicado: (2013)

The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells
por: Ogara, Maria F, et al.
Publicado: (2019)

Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodeling in dendritic cells
por: Morante-Palacios, Octavio, et al.
Publicado: (2021)

Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components
por: Ugur, Enes, et al.
Publicado: (2023)

Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression
por: Paschos, Kostas, et al.
Publicado: (2017)

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis
por: Lai, Binbin, et al.
Publicado: (2017)

Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation
por: Wedel, Miriam, et al.
Publicado: (2020)

Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system
por: Elsesser, Olga, et al.
Publicado: (2019)

Protein-mediated looping of DNA under tension requires supercoiling
por: Yan, Yan, et al.
Publicado: (2018)

Characterization of the DNA binding specificity of Shelterin complexes
por: Choi, Kyung H., et al.
Publicado: (2011)

Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms
por: Turner, Jonathan D., et al.
Publicado: (2008)

Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain
por: Stuss, David P., et al.
Publicado: (2013)

Evidence for a bind-then-bend mechanism for architectural DNA binding protein yNhp6A
por: Sarangi, Manas Kumar, et al.
Publicado: (2019)

Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing
por: Genest, Paul-Andre, et al.
Publicado: (2015)

Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination
por: Wüst, Hannah M, et al.
Publicado: (2020)

Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency
por: Qin, Weihua, et al.
Publicado: (2021)

Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors
por: Chen, Xi, et al.
Publicado: (2016)

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
por: Greulich, Franziska, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u5b0l6ntqvg5ve8sustlho3o8e