The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation

Sophoridine is a quinolizidine natural product and the exploration of its derivatives has been carried out, and the potent anticancer compound IMB-HDC was acquired. Although previous studies have revealed that some sophoridine derivatives could induce DNA breakage, the underlying mechanisms of inhib...

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Detalles Bibliográficos
Autores principales: Zhao, Wu-li, Xing, Yan, Ye, Cheng, Qiu, Yu-han, Li, Yi, Liu, Xiu-jun, Wang, Meng-yan, Bi, Chong-wen, Song, Dan-qing, Shao, Rong-guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471404/
https://www.ncbi.nlm.nih.gov/pubmed/31932645
http://dx.doi.org/10.1038/s41401-019-0333-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471404/
https://www.ncbi.nlm.nih.gov/pubmed/31932645
http://dx.doi.org/10.1038/s41401-019-0333-6

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