EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells

KRAS is one of the most important proto-oncogenes. Its mutations occur in almost all tumor types, and KRAS mutant cancer is still lack of effective therapy. Prenyl-binding protein phosphodiesterase-δ (PDEδ) is required for the plasma membrane association and subsequent activation of KRAS oncogenic s...

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Detalles Bibliográficos
Autores principales: Chen, Yue-hong, Lv, Hao, Shen, Ning, Wang, Xiao-min, Tang, Shuai, Xiong, Bing, Ding, Jian, Geng, Mei-yu, Huang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471410/
https://www.ncbi.nlm.nih.gov/pubmed/31316177
http://dx.doi.org/10.1038/s41401-019-0268-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471410/
https://www.ncbi.nlm.nih.gov/pubmed/31316177
http://dx.doi.org/10.1038/s41401-019-0268-y

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