Cargando…
EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells
KRAS is one of the most important proto-oncogenes. Its mutations occur in almost all tumor types, and KRAS mutant cancer is still lack of effective therapy. Prenyl-binding protein phosphodiesterase-δ (PDEδ) is required for the plasma membrane association and subsequent activation of KRAS oncogenic s...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Singapore
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471410/ https://www.ncbi.nlm.nih.gov/pubmed/31316177 http://dx.doi.org/10.1038/s41401-019-0268-y |