Cargando…

Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression

Tumor‐specific metabolic rewiring, acquired to confer a proliferative and survival advantage over nontransformed cells, represents a renewed focus in cancer therapy development. Hepatocellular carcinoma (HCC), a malignancy that has hitherto been resistant to compounds targeting oncogenic signaling p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chong, Yong Chun, Toh, Tan Boon, Chan, Zhiling, Lin, Quy Xiao Xuan, Thng, Dexter Kai Hao, Hooi, Lissa, Ding, Zhaobing, Shuen, Timothy, Toh, Han Chong, Dan, Yock Young, Bonney, Glenn Kunnath, Zhou, Lei, Chow, Pierce, Wang, Yulan, Benoukraf, Touati, Chow, Edward Kai‐Hua, Han, Weiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471427/ https://www.ncbi.nlm.nih.gov/pubmed/32923839 http://dx.doi.org/10.1002/hep4.1559

Ejemplares similares

Splice‐switch oligonucleotide‐based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC‐driven hepatocellular carcinoma
por: Thng, Dexter Kai Hao, et al.
Publicado: (2022)

Histone‐lysine N‐methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc‐driven liver cancer
por: Thng, Dexter Kai Hao, et al.
Publicado: (2023)

Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors
por: Lim, Jhin Jieh, et al.
Publicado: (2022)

Datasets describing the growth and molecular features of hepatocellular carcinoma patient-derived xenograft cells grown in a three-dimensional macroporous hydrogel
por: Fong, Eliza Li Shan, et al.
Publicado: (2018)

Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer
por: Tay, Daryl Jin Tai, et al.
Publicado: (2021)

Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy
por: Zhao, Yue, et al.
Publicado: (2018)

JAK/STAT signaling in hepatocellular carcinoma
por: Hin Tang, Justin Jit, et al.
Publicado: (2020)

Nanodiamond–Mitoxantrone Complexes Enhance Drug Retention in Chemoresistant Breast Cancer Cells
por: Toh, Tan-Boon, et al.
Publicado: (2014)

Epigenetics in cancer stem cells
por: Toh, Tan Boon, et al.
Publicado: (2017)

Epigenetics of hepatocellular carcinoma
por: Toh, Tan Boon, et al.
Publicado: (2019)

Eph receptor B2 (EPHB2) regulates cancer stem cell-like properties in hepatocellular carcinoma
por: Lim, Jhin Jieh, et al.
Publicado: (2022)

TFregulomeR reveals transcription factors’ context-specific features and functions
por: Lin, Quy Xiao Xuan, et al.
Publicado: (2020)

Tailoring precision immunotherapy: coming to a clinic soon?
por: Han, Shuting, et al.
Publicado: (2020)

Epirubicin-Adsorbed Nanodiamonds Kill Chemoresistant Hepatic Cancer Stem Cells
por: Wang, Xin, et al.
Publicado: (2014)

MethMotif: an integrative cell specific database of transcription factor binding motifs coupled with DNA methylation profiles
por: Xuan Lin, Quy Xiao, et al.
Publicado: (2019)

Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma
por: Jin, Yu, et al.
Publicado: (2019)

Extracellular Vesicles May Predict Response to Radioembolization and Sorafenib Treatment in Advanced Hepatocellular Carcinoma: An Exploratory Analysis from the SORAMIC Trial
por: Shuen, Timothy Wai Ho, et al.
Publicado: (2022)

A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes
por: Wuestefeld, Anna, et al.
Publicado: (2023)

RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma
por: Huynh, Hung, et al.
Publicado: (2009)

Correspondence on NanoVar’s performance outlined by Jiang T. et al. in “Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation”
por: Tham, Cheng Yong, et al.
Publicado: (2023)

Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma
por: Zhang, Xi Yun, et al.
Publicado: (2020)

Awakening immunity against cancer: a 2017 primer for clinicians
por: Jain, Amit, et al.
Publicado: (2017)

Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease
por: Adusumalli, Swarnaseetha, et al.
Publicado: (2019)

Mechanisms of chemoresistance in cancer stem cells
por: Abdullah, Lissa Nurrul, et al.
Publicado: (2013)

MicroRNA-224 Targets SMAD Family Member 4 to Promote Cell Proliferation and Negatively Influence Patient Survival
por: Wang, Yu, et al.
Publicado: (2013)

The utility of Aspirin in dukes C and high risk dukes B colorectal cancer - The ASCOLT study: study protocol for a randomized controlled trial
por: Ali, Raghib, et al.
Publicado: (2011)

Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy
por: Chew, Valerie, et al.
Publicado: (2012)

Methylation Profiles Reveal Distinct Subgroup of Hepatocellular Carcinoma Patients with Poor Prognosis
por: Mah, Way-Champ, et al.
Publicado: (2014)

Correction: Methylation Profiles Reveal Distinct Subgroup of Hepatocellular Carcinoma Patients with Poor Prognosis
por: Mah, Way-Champ, et al.
Publicado: (2016)

Revisiting the role of CD4(+) T cells in cancer immunotherapy—new insights into old paradigms
por: Tay, Rong En, et al.
Publicado: (2020)

SARS-COV-2 associated acute pancreatitis: Cause, consequence or epiphenomenon?
por: Bonney, Glenn Kunnath, et al.
Publicado: (2020)

Organoids as an Enabler of Precision Immuno-Oncology
por: Zhao, Junzhe, et al.
Publicado: (2023)

The Purins
por: Hopkins, Henry Reed
Publicado: (1910)

miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set
por: Abdul Hadi, Luqman Hakim, et al.
Publicado: (2018)

Addressing antimicrobial resistance with the IDentif.AI platform: Rapidly optimizing clinically actionable combination therapy regimens against nontuberculous mycobacteria
por: Mukherjee, Devika, et al.
Publicado: (2022)

The Role of Five Facets of Mindfulness in a Mindfulness-Based Psychoeducation Intervention for People With Recent-Onset Psychosis on Mental and Psychosocial Health Outcomes
por: Chien, Wai Tong, et al.
Publicado: (2020)

25-Hydroxyvitamin D(3) induces osteogenic differentiation of human mesenchymal stem cells
por: Lou, Yan-Ru, et al.
Publicado: (2017)

THE PURINES AND PURINE METABOLISM OF SOME TUMORS IN DOMESTIC ANIMALS
por: Long, Esmond R.
Publicado: (1913)

English as medium of instruction in Japanese higher education: presumption, mirage or bluff?
por: Toh, Glenn
Publicado: (2016)

Effecting change in English language teaching: exposing collaborators and culprits in Japan
por: Toh, Glenn
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_nf49alv9eri0a91pkkutkesbji