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TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson’s disease

Parkinson’s disease (PD) is a multifactorial disorder characterized by progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies (LBs) consisting of misfolded α-synuclein protein. The etiology of PD is still not clear but systemic infl...

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Detalles Bibliográficos
Autores principales: Shao, Qian-hang, Chen, Ying, Li, Fang-fang, Wang, Shuo, Zhang, Xiao-ling, Yuan, Yu-he, Chen, Nai-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471440/
https://www.ncbi.nlm.nih.gov/pubmed/31388087
http://dx.doi.org/10.1038/s41401-019-0280-2