3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways, especially the JAK2/STAT3 pathway, play vital roles in the development of many malignancies. Overactivation of STAT3 promotes cancer cell survival and proliferation. Therefore, the JAK2/STAT3-signaling pathway h...

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Detalles Bibliográficos
Autores principales: Shan, Hui, Yao, Sheng, Ye, Yang, Yu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471446/
https://www.ncbi.nlm.nih.gov/pubmed/31201357
http://dx.doi.org/10.1038/s41401-019-0254-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471446/
https://www.ncbi.nlm.nih.gov/pubmed/31201357
http://dx.doi.org/10.1038/s41401-019-0254-4

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