Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core

Nav1.7 channels are mainly distributed in the peripheral nervous system. Blockade of Nav1.7 channels with small-molecule inhibitors in humans might provide pain relief without affecting the central nervous system. Based on the facts that many reported Nav1.7-selective inhibitors contain aryl sulfona...

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Detalles Bibliográficos
Autores principales: Wang, Jin-tao, Zheng, Yue-ming, Chen, Yue-ting, Gu, Min, Gao, Zhao-bing, Nan, Fa-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471454/
https://www.ncbi.nlm.nih.gov/pubmed/31316182
http://dx.doi.org/10.1038/s41401-019-0267-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471454/
https://www.ncbi.nlm.nih.gov/pubmed/31316182
http://dx.doi.org/10.1038/s41401-019-0267-z

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