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PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats
Sunitinib is an oral small molecule multitargeted tyrosine kinase inhibitor, which is currently used to treat severe cancers. Clinical research has shown that patients treated with sunitinib develop hypertension. As soon as sunitinib-induced hypertension appears, it is usual to administer anti-hyper...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Singapore
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471499/ https://www.ncbi.nlm.nih.gov/pubmed/31932646 http://dx.doi.org/10.1038/s41401-019-0331-8 |