Cargando…

Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy

Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in GBM and assessed the role of fatty acid oxidation (FAO) in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sperry, Jantzen, Condro, Michael C., Guo, Lea, Braas, Daniel, Vanderveer-Harris, Nathan, Kim, Kristen K.O., Pope, Whitney B., Divakaruni, Ajit S., Lai, Albert, Christofk, Heather, Castro, Maria G., Lowenstein, Pedro R., Le Belle, Janel E., Kornblum, Harley I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471621/ https://www.ncbi.nlm.nih.gov/pubmed/32861192 http://dx.doi.org/10.1016/j.isci.2020.101453

Ejemplares similares

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells
por: Le Belle, Janel E., et al.
Publicado: (2014)

The Ketogenic Diet Revisited: Beyond Ketones
por: Sourbron, Jo, et al.
Publicado: (2021)

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
por: Garrett, Matthew, et al.
Publicado: (2018)

Starvation Ketoacidosis Induced by Ketogenic Diet and Consumption of Ketone Supplement
por: Malhi, Manjot S, et al.
Publicado: (2021)

Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention
por: Saris, Christiaan G. J., et al.
Publicado: (2022)

Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters
por: Nasser, Souad, et al.
Publicado: (2020)

Ketogenic diet versus ketoacidosis: what determines the influence of ketone bodies on neurons?
por: Fedorovich, Sergei V., et al.
Publicado: (2018)

Acute Ketogenic Diet and Ketone Ester Supplementation Impairs Race Walk Performance
por: WHITFIELD, JAMIE, et al.
Publicado: (2021)

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade
por: Ferrere, Gladys, et al.
Publicado: (2021)

Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet
por: Liśkiewicz, Daniela, et al.
Publicado: (2021)

Ketogenic Diet in the Treatment of Gliomas and Glioblastomas
por: Dal Bello, Simone, et al.
Publicado: (2022)

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions
por: Miyamoto, Junki, et al.
Publicado: (2019)

Efficacy and Safety of Ketone Supplementation or Ketogenic Diets for Alzheimer's Disease: A Mini Review
por: Lilamand, Matthieu, et al.
Publicado: (2022)

Ketogenic Diet and Ketone Bodies against Ischemic Injury: Targets, Mechanisms, and Therapeutic Potential
por: Makievskaya, Ciara I., et al.
Publicado: (2023)

Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism
por: Khouri, Hannah, et al.
Publicado: (2023)

Impact of ketogenic diet and ketone diester supplementation on body weight, blood glucose, and ketones in Sprague Dawley rats fed over two weeks
por: Modica, LT Claire M., et al.
Publicado: (2021)

The dark side of the spoon - glucose, ketones and COVID-19: a possible role for ketogenic diet?
por: Paoli, Antonio, et al.
Publicado: (2020)

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
por: Krall, Abigail S., et al.
Publicado: (2016)

The Influence of the Ketogenic Diet on the Immune Tolerant Microenvironment in Glioblastoma
por: Kesarwani, Pravin, et al.
Publicado: (2022)

Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy
por: Qian, Liyuan, et al.
Publicado: (2021)

Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders
por: Spigoni, Valentina, et al.
Publicado: (2022)

Ketogenic Diet and Ketone Bodies as Clinical Support for the Treatment of SARS-CoV-2—Review of the Evidence
por: Bolesławska, Izabela, et al.
Publicado: (2023)

Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma
por: Patel, Kunal S., et al.
Publicado: (2020)

The Role of Ketone Bodies in Treatment Individualization of Glioblastoma Patients
por: Tamas, Corina, et al.
Publicado: (2023)

OMRT-5. Therapy-induced reprogramming drives glioma vascular transdifferentiation and recurrence
por: Muthukrishnan, Sree Deepthi, et al.
Publicado: (2021)

Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies
por: Mantis, John G, et al.
Publicado: (2004)

Neuroprotective effects of a ketogenic diet in combination with exogenous ketone salts following acute spinal cord injury
por: Tan, Bo-Tao, et al.
Publicado: (2020)

Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States
por: Dąbek, Arkadiusz, et al.
Publicado: (2020)

ERGO: A pilot study of ketogenic diet in recurrent glioblastoma
por: RIEGER, JOHANNES, et al.
Publicado: (2014)

Fenofibrate Induces Ketone Body Production in Melanoma and Glioblastoma Cells
por: Grabacka, Maja M., et al.
Publicado: (2016)

Identification of an Efficient Gene Expression Panel for Glioblastoma Classification
por: Crisman, Thomas J., et al.
Publicado: (2016)

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
por: Maurer, Gabriele D, et al.
Publicado: (2011)

The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses
por: Buga, Alex, et al.
Publicado: (2021)

Ketogenic therapies for glioblastoma: Understanding the limitations in transitioning from mice to patients
por: Clontz, Angela D.
Publicado: (2023)

OTEH-8. Pathway-based approach reveals sensitivity to radiation when targeting E2F1 in Glioblastoma
por: Alvarado, Alvaro, et al.
Publicado: (2021)

P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells
por: Muthukrishnan, Sree Deepthi, et al.
Publicado: (2022)

Comparison of Ketogenic Diets with and without Ketone Salts versus a Low-Fat Diet: Liver Fat Responses in Overweight Adults
por: Crabtree, Christopher D., et al.
Publicado: (2021)

Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy
por: Poff, A. M., et al.
Publicado: (2015)

Ketone production by ketogenic diet and by intermittent fasting has different effects on the gut microbiota and disease progression in an Alzheimer’s disease rat model
por: Park, Sunmin, et al.
Publicado: (2020)

Enantioselective Nickel‐Catalyzed anti‐Arylmetallative Cyclizations onto Acyclic Ketones
por: Green, Harley, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hus8kaqojb2vmoj3tstr77d9iv