Co-expression of a SARP Family Activator ChlF2 and a Type II Thioesterase ChlK Led to High Production of Chlorothricin in Streptomyces antibioticus DSM 40725

Chlorothricin (CHL), produced by Streptomyces antibioticus DSM 40725 (wild-type strain, WT), belongs to a growing family of spirotetronate antibiotics that have biological activities inhibiting pyruvate carboxylase and malate dehydrogenase. ChlF2, a cluster-situated SARP regulator, can activate the...

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Detalles Bibliográficos
Autores principales: Li, Yue, Zhang, Jihui, Zheng, Jiazhen, Guan, Hanye, Liu, Wen, Tan, Huarong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471628/
https://www.ncbi.nlm.nih.gov/pubmed/32974326
http://dx.doi.org/10.3389/fbioe.2020.01013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471628/
https://www.ncbi.nlm.nih.gov/pubmed/32974326
http://dx.doi.org/10.3389/fbioe.2020.01013

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