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Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain

Patients with membranous nephropathy have autoantibodies against PLA2R (up to 80%), or THSD7A (up to 2%). We previously described the immunodominant epitope within PLA2R but epitopes in THSD7A are still unknown. To find anti-THSD7A sera for this study, we screened 1843 sera from biopsy-proven MN pat...

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Detalles Bibliográficos
Autores principales: Fresquet, M., Rhoden, S.J., Jowitt, T.A., McKenzie, E.A., Roberts, I., Lennon, R., Brenchley, P.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471840/
https://www.ncbi.nlm.nih.gov/pubmed/31395435
http://dx.doi.org/10.1016/j.jaut.2019.102308