α-Conotoxin Peptidomimetics: Probing the Minimal Binding Motif for Effective Analgesia

Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets—nicotinic acetylcholine and γ-aminobutyric acid (GABA) G protein-coupled (GABA(B)) receptors. Both...

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Detalles Bibliográficos
Autores principales: Kennedy, Adam C., Belgi, Alessia, Husselbee, Benjamin W., Spanswick, David, Norton, Raymond S., Robinson, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472027/
https://www.ncbi.nlm.nih.gov/pubmed/32781580
http://dx.doi.org/10.3390/toxins12080505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472027/
https://www.ncbi.nlm.nih.gov/pubmed/32781580
http://dx.doi.org/10.3390/toxins12080505

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