Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Tetrodotoxin (TTX) is a highly specific voltage-gated sodium channel (VGSC) blocker in clinical evaluation as a peripheral-acting analgesic for chronic pain. This study presents the first published results of the safety including cardiac liability of TTX at therapeutic-relevant concentrations in twe...

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Detalles Bibliográficos
Autores principales: Kavoosi, Mojgan, O’Reilly, Terry E., Kavoosi, Mehran, Chai, Peng, Engel, Caroline, Korz, Walter, Gallen, Christopher C., Lester, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472037/
https://www.ncbi.nlm.nih.gov/pubmed/32784930
http://dx.doi.org/10.3390/toxins12080511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472037/
https://www.ncbi.nlm.nih.gov/pubmed/32784930
http://dx.doi.org/10.3390/toxins12080511

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