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Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Tetrodotoxin (TTX) is a highly specific voltage-gated sodium channel (VGSC) blocker in clinical evaluation as a peripheral-acting analgesic for chronic pain. This study presents the first published results of the safety including cardiac liability of TTX at therapeutic-relevant concentrations in twe...

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Detalles Bibliográficos
Autores principales:	Kavoosi, Mojgan, O’Reilly, Terry E., Kavoosi, Mehran, Chai, Peng, Engel, Caroline, Korz, Walter, Gallen, Christopher C., Lester, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472037/ https://www.ncbi.nlm.nih.gov/pubmed/32784930 http://dx.doi.org/10.3390/toxins12080511

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