Fact and Fiction about 1%: Next Generation Sequencing and the Detection of Minor Drug Resistant Variants in HIV-1 Populations with and without Unique Molecular Identifiers

Next generation sequencing (NGS) platforms have the ability to generate almost limitless numbers of sequence reads starting with a PCR product. This gives the illusion that it is possible to analyze minor variants in a viral population. However, including a PCR step obscures the sampling depth of th...

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Detalles Bibliográficos
Autores principales: Zhou, Shuntai, Swanstrom, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472098/
https://www.ncbi.nlm.nih.gov/pubmed/32759675
http://dx.doi.org/10.3390/v12080850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472098/
https://www.ncbi.nlm.nih.gov/pubmed/32759675
http://dx.doi.org/10.3390/v12080850

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