Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data

Many drugs investigated for the treatment of glioblastoma (GBM) have had disappointing clinical trial results. Efficacy of these agents is dependent on adequate delivery to sensitive tumor cell populations, which is limited by the blood-brain barrier (BBB). Additionally, tumor heterogeneity can lead...

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Detalles Bibliográficos
Autores principales: Massey, Susan Christine, Urcuyo, Javier C., Marin, Bianca Maria, Sarkaria, Jann N., Swanson, Kristin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472531/
https://www.ncbi.nlm.nih.gov/pubmed/32973540
http://dx.doi.org/10.3389/fphys.2020.00830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472531/
https://www.ncbi.nlm.nih.gov/pubmed/32973540
http://dx.doi.org/10.3389/fphys.2020.00830

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