Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

Human CYP3A enzymes (including CYP3A4 and CYP4A5) metabolize about 40% of all drugs and numerous other environmental and endogenous substances. CYP3A activity is highly variable within and between humans. As a consequence, therapy with standard doses often results in too low or too high blood and ti...

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Detalles Bibliográficos
Autores principales: Matthaei, Johannes, Bonat, Wagner Hugo, Kerb, Reinhold, Tzvetkov, Mladen Vassilev, Strube, Jakob, Brunke, Stefanie, Sachse-Seeboth, Cordula, Sehrt, Daniel, Hofmann, Ute, von Bornemann Hjelmborg, Jacob, Schwab, Matthias, Brockmöller, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472781/
https://www.ncbi.nlm.nih.gov/pubmed/32973880
http://dx.doi.org/10.3389/fgene.2020.00944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472781/
https://www.ncbi.nlm.nih.gov/pubmed/32973880
http://dx.doi.org/10.3389/fgene.2020.00944

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