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Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities

Alcohol consumption often leads to hangover, a condition characterized by several symptoms, characteristically headache, nausea, fatigue and drowsiness. Hangover may be alleviated by altering the rate of alcohol metabolism and facilitating elimination of acetaldehyde by affecting the activity of alc...

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Autores principales: Srinivasan, Shraddha, Dubey, Kriti Kumari, Singhal, Rekha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473379/
https://www.ncbi.nlm.nih.gov/pubmed/32914100
http://dx.doi.org/10.1016/j.crfs.2019.09.001
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author Srinivasan, Shraddha
Dubey, Kriti Kumari
Singhal, Rekha S.
author_facet Srinivasan, Shraddha
Dubey, Kriti Kumari
Singhal, Rekha S.
author_sort Srinivasan, Shraddha
collection PubMed
description Alcohol consumption often leads to hangover, a condition characterized by several symptoms, characteristically headache, nausea, fatigue and drowsiness. Hangover may be alleviated by altering the rate of alcohol metabolism and facilitating elimination of acetaldehyde by affecting the activity of alcohol dehydrogenase (ADH) and/or aldehyde dehydrogenase (ALDH) enzymes. In the present study, several food commodities like fruits, vegetables, cereals, pulses, dairy products, spices and other miscellaneous products (ascorbic acid, cocoa sample, tea, coffee, egg yolk and date samples) were investigated for their effect on the in vitro activities of the enzymes and their antioxidant properties. Of the many screened food commodities, few showed an increase in the activity of either one or both the enzymes, ADH and ALDH. Studies showed no correlation between ADH and ALDH enzyme activities and antioxidant property of the selected food commodities for anti-hangover effect. Further, an anti-hangover (AHO) product was developed using pear (65%), sweet lime (25%) and coconut water (10%) and, validated for in vitro ADH and ALDH enzyme activities. AHO product was found to enhance ADH and ALDH activities by 23.31% and 70.02%, respectively.
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spelling pubmed-74733792020-09-09 Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities Srinivasan, Shraddha Dubey, Kriti Kumari Singhal, Rekha S. Curr Res Food Sci Article Alcohol consumption often leads to hangover, a condition characterized by several symptoms, characteristically headache, nausea, fatigue and drowsiness. Hangover may be alleviated by altering the rate of alcohol metabolism and facilitating elimination of acetaldehyde by affecting the activity of alcohol dehydrogenase (ADH) and/or aldehyde dehydrogenase (ALDH) enzymes. In the present study, several food commodities like fruits, vegetables, cereals, pulses, dairy products, spices and other miscellaneous products (ascorbic acid, cocoa sample, tea, coffee, egg yolk and date samples) were investigated for their effect on the in vitro activities of the enzymes and their antioxidant properties. Of the many screened food commodities, few showed an increase in the activity of either one or both the enzymes, ADH and ALDH. Studies showed no correlation between ADH and ALDH enzyme activities and antioxidant property of the selected food commodities for anti-hangover effect. Further, an anti-hangover (AHO) product was developed using pear (65%), sweet lime (25%) and coconut water (10%) and, validated for in vitro ADH and ALDH enzyme activities. AHO product was found to enhance ADH and ALDH activities by 23.31% and 70.02%, respectively. Elsevier 2019-09-17 /pmc/articles/PMC7473379/ /pubmed/32914100 http://dx.doi.org/10.1016/j.crfs.2019.09.001 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Srinivasan, Shraddha
Dubey, Kriti Kumari
Singhal, Rekha S.
Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
title Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
title_full Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
title_fullStr Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
title_full_unstemmed Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
title_short Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
title_sort influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473379/
https://www.ncbi.nlm.nih.gov/pubmed/32914100
http://dx.doi.org/10.1016/j.crfs.2019.09.001
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