Functional information from clinically-derived drug resistant forms of the Candida glabrata Pdr1 transcription factor

Azole drugs are the most frequently used antifungal agents. The pathogenic yeast Candida glabrata acquires resistance to azole drugs via single amino acid substitution mutations eliciting a gain-of-function (GOF) hyperactive phenotype in the Pdr1 transcription factor. These GOF mutants constitutivel...

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Detalles Bibliográficos
Autores principales: Simonicova, Lucia, Moye-Rowley, W. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473514/
https://www.ncbi.nlm.nih.gov/pubmed/32841236
http://dx.doi.org/10.1371/journal.pgen.1009005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473514/
https://www.ncbi.nlm.nih.gov/pubmed/32841236
http://dx.doi.org/10.1371/journal.pgen.1009005

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