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Functional information from clinically-derived drug resistant forms of the Candida glabrata Pdr1 transcription factor
Azole drugs are the most frequently used antifungal agents. The pathogenic yeast Candida glabrata acquires resistance to azole drugs via single amino acid substitution mutations eliciting a gain-of-function (GOF) hyperactive phenotype in the Pdr1 transcription factor. These GOF mutants constitutivel...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473514/ https://www.ncbi.nlm.nih.gov/pubmed/32841236 http://dx.doi.org/10.1371/journal.pgen.1009005 |