A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases

Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of genetic diseases. NMD also limits the efficiency...

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Detalles Bibliográficos
Autores principales: Echols, Josh, Siddiqui, Amna, Dai, Yanying, Havasi, Viktoria, Sun, Richard, Kaczmarczyk, Aneta, Keeling, Kim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473645/
https://www.ncbi.nlm.nih.gov/pubmed/32737261
http://dx.doi.org/10.1242/dmm.044891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473645/
https://www.ncbi.nlm.nih.gov/pubmed/32737261
http://dx.doi.org/10.1242/dmm.044891

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