Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells

Cystic fibrosis (CF) is a genetic disease characterized by progressive lung and chronic digestive manifestations. We have shown that therapeutic doses of vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor, corrects CF Transmembrane conductance Regulator (CFTR)-dependent chloride transport in re...

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Detalles Bibliográficos
Autores principales: Dhooghe, Barbara, Bouzin, Caroline, Mottais, Angélique, Hermans, Emmanuel, Delion, Martial, Panin, Nadtha, Noel, Sabrina, Leal, Teresinha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473651/
https://www.ncbi.nlm.nih.gov/pubmed/32747447
http://dx.doi.org/10.1242/bio.053116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473651/
https://www.ncbi.nlm.nih.gov/pubmed/32747447
http://dx.doi.org/10.1242/bio.053116

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