Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca(2+), and activate NFAT and Akt signaling

Dilated cardiomyopathy (DCM) is clinically characterized by dilated ventricular cavities and reduced ejection fraction, leading to heart failure and increased thromboembolic risk. Mutations in thin-filament regulatory proteins can cause DCM and have been shown in vitro to reduce contractility and my...

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Detalles Bibliográficos
Autores principales: Robinson, Paul, Sparrow, Alexander J., Patel, Suketu, Malinowska, Marta, Reilly, Svetlana N., Zhang, Yin-Hua, Casadei, Barbara, Watkins, Hugh, Redwood, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473929/
https://www.ncbi.nlm.nih.gov/pubmed/32618513
http://dx.doi.org/10.1152/ajpheart.00272.2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473929/
https://www.ncbi.nlm.nih.gov/pubmed/32618513
http://dx.doi.org/10.1152/ajpheart.00272.2020

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