Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate

PURPOSE: This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding in vitro to in vivo translation of target modulation. METHOD...

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Detalles Bibliográficos
Autores principales: Ballard, Jeanine E., Pall, Parul, Vardigan, Joshua, Zhao, Fuqiang, Holahan, Marie A., Kraus, Richard, Li, Yuxing, Henze, Darrell, Houghton, Andrea, Burgey, Christopher S., Gibson, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473964/
https://www.ncbi.nlm.nih.gov/pubmed/32888082
http://dx.doi.org/10.1007/s11095-020-02914-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473964/
https://www.ncbi.nlm.nih.gov/pubmed/32888082
http://dx.doi.org/10.1007/s11095-020-02914-9

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