Preformulation Studies of a Stable PTEN-PDZ Lipopeptide Able to Cross an In Vitro Blood-Brain-Barrier Model as a Potential Therapy for Alzheimer’s Disease

PURPOSE: Amyloid β (Aβ) drives the accumulation of excess Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) at synapses, inducing synaptic depression and perturbing memory. This recruitment of PTEN to synapses in response to Aβ drives its interaction with PSD95/Disc large/Zonula occlude...

Descripción completa

Detalles Bibliográficos
Autores principales: Lalatsa, Aikaterini, Sun, Yujiao, Gamboa, Jose Ignacio, Knafo, Shira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473970/
https://www.ncbi.nlm.nih.gov/pubmed/32888078
http://dx.doi.org/10.1007/s11095-020-02915-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473970/
https://www.ncbi.nlm.nih.gov/pubmed/32888078
http://dx.doi.org/10.1007/s11095-020-02915-8

Ejemplares similares