Single-Cell Sequencing of Mouse Thymocytes Reveals Mutational Landscape Shaped by Replication Errors, Mismatch Repair, and H3K36me3

DNA mismatch repair (MMR) corrects replication errors and is recruited by the histone mark H3K36me3, enriched in exons of transcriptionally active genes. To dissect in vivo the mutational landscape shaped by these processes, we employed single-cell exome sequencing on T cells of wild-type and MMR-de...

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Detalles Bibliográficos
Autores principales: Aska, Elli-Mari, Dermadi, Denis, Kauppi, Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474001/
https://www.ncbi.nlm.nih.gov/pubmed/32858340
http://dx.doi.org/10.1016/j.isci.2020.101452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474001/
https://www.ncbi.nlm.nih.gov/pubmed/32858340
http://dx.doi.org/10.1016/j.isci.2020.101452

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