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Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors

BACKGROUND & AIMS: Colonic musculature contain smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and platelet-derived growth factor receptor α(+) cells (PDGFRα(+) cells), which are electrically coupled and operate together as the SIP syncytium. PDGFRα(+) cells have enriched expressio...

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Detalles Bibliográficos
Autores principales:	Kurahashi, Masaaki, Kito, Yoshihiko, Hara, Masayasu, Takeyama, Hiromitsu, Sanders, Kenton M., Hashitani, Hikaru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474159/ https://www.ncbi.nlm.nih.gov/pubmed/32376421 http://dx.doi.org/10.1016/j.jcmgh.2020.04.015

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