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Crystallographic evidence for unintended benzisothiazolinone 1-oxide formation from benzothiazinones through oxidation
1,3-Benzothiazin-4-ones (BTZs) are a promising new class of drugs with activity against Mycobacterium tuberculosis, which have already reached clinical trials. A product obtained in low yield upon treatment of 8-nitro-2-(piperidin-1-yl)-6-(trifluoromethyl)-4H-benzothiazin-4-one with 3-chloro...
Autores principales: | Eckhardt, Tamira, Goddard, Richard, Lehmann, Christoph, Richter, Adrian, Sahile, Henok Asfaw, Liu, Rui, Tiwari, Rohit, Oliver, Allen G., Miller, Marvin J., Seidel, Rüdiger W., Imming, Peter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474187/ https://www.ncbi.nlm.nih.gov/pubmed/32887862 http://dx.doi.org/10.1107/S2053229620010931 |
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