Mechanical Unfolding of Proteins—A Comparative Nonequilibrium Molecular Dynamics Study

Mechanical signals regulate functions of mechanosensitive proteins by inducing structural changes that are determinant for force-dependent interactions. Talin is a focal adhesion protein that is known to extend under mechanical load, and it has been shown to unfold via intermediate states. Here, we...

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Detalles Bibliográficos
Autores principales: Mykuliak, Vasyl V., Sikora, Mateusz, Booth, Jonathan J., Cieplak, Marek, Shalashilin, Dmitrii V., Hytönen, Vesa P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474207/
https://www.ncbi.nlm.nih.gov/pubmed/32822586
http://dx.doi.org/10.1016/j.bpj.2020.07.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474207/
https://www.ncbi.nlm.nih.gov/pubmed/32822586
http://dx.doi.org/10.1016/j.bpj.2020.07.030

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