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Nuclear mechanosensing controls MSC osteogenic potential through HDAC epigenetic remodeling
Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor and can directly influence chromatin organization, epigenetic modifications, and gene expression. Dysregulation of nuclear m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474590/ https://www.ncbi.nlm.nih.gov/pubmed/32817542 http://dx.doi.org/10.1073/pnas.2006765117 |