Enhancer dependence of cell-type–specific gene expression increases with developmental age

How overall principles of cell-type–specific gene regulation (the “logic”) may change during ontogeny is largely unexplored. We compared transcriptomic, epigenomic, and three-dimensional (3D) genomic profiles in embryonic (EryP) and adult (EryD) erythroblasts. Despite reduced chromatin accessibility...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Wenqing, Huang, Jialiang, Zhu, Qian, Li, Bin E., Seruggia, Davide, Zhou, Pingzhu, Nguyen, Minh, Fujiwara, Yuko, Xie, Huafeng, Yang, Zhenggang, Hong, Danni, Ren, Pengfei, Xu, Jian, Pu, William T., Yuan, Guo-Cheng, Orkin, Stuart H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474592/
https://www.ncbi.nlm.nih.gov/pubmed/32817427
http://dx.doi.org/10.1073/pnas.2008672117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474592/
https://www.ncbi.nlm.nih.gov/pubmed/32817427
http://dx.doi.org/10.1073/pnas.2008672117

Ejemplares similares