Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer

We tested cis-Apc(Δ716)/Smad4(+/−) and cis-Apc(Δ716)/Smad4(+/−) Kras(G12D) mice, which recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis in humans, for responsiveness to anti-VEGF therapy. We found that even tumors in cis-Apc(Δ716)/Smad4(+/−) Kras(G12D)...

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Detalles Bibliográficos
Autores principales: Itatani, Yoshiro, Yamamoto, Takamasa, Zhong, Cuiling, Molinolo, Alfredo A., Ruppel, Jane, Hegde, Priti, Taketo, M. Mark, Ferrara, Napoleone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474657/
https://www.ncbi.nlm.nih.gov/pubmed/32817421
http://dx.doi.org/10.1073/pnas.2008112117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474657/
https://www.ncbi.nlm.nih.gov/pubmed/32817421
http://dx.doi.org/10.1073/pnas.2008112117

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