Phosphorylated CtIP bridges DNA to promote annealing of broken ends

The early steps of DNA double-strand break (DSB) repair in human cells involve the MRE11-RAD50-NBS1 (MRN) complex and its cofactor, phosphorylated CtIP. The roles of these proteins in nucleolytic DSB resection are well characterized, but their role in bridging the DNA ends for efficient and correct...

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Detalles Bibliográficos
Autores principales: Öz, Robin, Howard, Sean M., Sharma, Rajhans, Törnkvist, Hanna, Ceppi, Ilaria, KK, Sriram, Kristiansson, Erik, Cejka, Petr, Westerlund, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474685/
https://www.ncbi.nlm.nih.gov/pubmed/32817418
http://dx.doi.org/10.1073/pnas.2008645117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474685/
https://www.ncbi.nlm.nih.gov/pubmed/32817418
http://dx.doi.org/10.1073/pnas.2008645117

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