The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations

Inorganic polyphosphate (polyP) is a morphogenetically active and metabolic energy-delivering physiological polymer that is released from blood platelets. Here, we show that polyP efficiently inhibits the binding of the envelope spike (S)-protein of the coronavirus SARS-CoV-2, the causative agent of...

Descripción completa

Detalles Bibliográficos
Autores principales: Neufurth, Meik, Wang, Xiaohong, Tolba, Emad, Lieberwirth, Ingo, Wang, Shunfeng, Schröder, Heinz C., Müller, Werner E.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474874/
https://www.ncbi.nlm.nih.gov/pubmed/32905794
http://dx.doi.org/10.1016/j.bcp.2020.114215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474874/
https://www.ncbi.nlm.nih.gov/pubmed/32905794
http://dx.doi.org/10.1016/j.bcp.2020.114215

Ejemplares similares