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Evolution of dependoparvoviruses across geological timescales—implications for design of AAV-based gene therapy vectors

Endogenous viral elements (EVEs) are genetic remnants of viruses that have integrated into host genomes millions of years ago and retained as heritable elements passed on to offspring until present-day. As a result, EVEs provide an opportunity to analyse the genomes of extinct viruses utilizing thes...

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Detalles Bibliográficos
Autores principales: Hildebrandt, Evin, Penzes, Judit J, Gifford, Robert J, Agbandje-Mckenna, Mavis, Kotin, Robert M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474932/
https://www.ncbi.nlm.nih.gov/pubmed/32913662
http://dx.doi.org/10.1093/ve/veaa043