Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth

The immunogenic clonal-fraction threshold in heterogeneous solid-tumor required to induce effective bystander-killing of non-immunogenic subclones is unknown. Pancreatic cancer poses crucial challenges for immune therapeutic interventions due to low mutational-burden and consequent lack of neoantige...

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Detalles Bibliográficos
Autores principales: Das, Manisit, Zhou, Xuefei, Liu, Yun, Das, Anirban, Vincent, Benjamin G., Li, Jingjing, Liu, Rihe, Huang, Leaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475277/
https://www.ncbi.nlm.nih.gov/pubmed/32862105
http://dx.doi.org/10.1016/j.tranon.2020.100856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475277/
https://www.ncbi.nlm.nih.gov/pubmed/32862105
http://dx.doi.org/10.1016/j.tranon.2020.100856

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