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Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs

As a dynamic regulator for short-lived protein degradation and turnover, the ubiquitin-proteasome system (UPS) plays important roles in various biological processes, including response to cellular stress, regulation of cell cycle progression, and carcinogenesis. Over the past decade, research on tar...

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Detalles Bibliográficos
Autores principales: Zheng, Shuhua, Tao, Wensi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475704/
https://www.ncbi.nlm.nih.gov/pubmed/32983997
http://dx.doi.org/10.3389/fonc.2020.01517