Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library

Objective: Osteosarcoma is the most common primary malignant bone tumor. However, the survival of patients with osteosarcoma has remained unchanged during the past 30 years, owing to a lack of efficient therapeutic targets. Methods: We constructed a kinome-targeting CRISPR-Cas9 library containing 50...

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Detalles Bibliográficos
Autores principales: Wu, Yuanzhong, Zhou, Liwen, Wang, Zifeng, Wang, Xin, Zhang, Ruhua, Zheng, Lisi, Kang, Tiebang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Compuscript 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476084/
https://www.ncbi.nlm.nih.gov/pubmed/32944406
http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476084/
https://www.ncbi.nlm.nih.gov/pubmed/32944406
http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0162

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