Preliminary report of in vitro and in vivo effectiveness of dornase alfa on SARS-CoV-2 infection

Dornase alfa, the recombinant form of the human DNase I enzyme, breaks down neutrophil extracellular traps (NET) that include a vast amount of DNA fragments, histones, microbicidal proteins and oxidant enzymes released from necrotic neutrophils in the highly viscous mucus of cystic fibrosis patients...

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Detalles Bibliográficos
Autores principales: Okur, H.K., Yalcin, K., Tastan, C., Demir, S., Yurtsever, B., Karakus, G.S., Kancagi, D.D., Abanuz, S., Seyis, U., Zengin, R., Hemsinlioglu, C., Kara, M., Yildiz, M.E., Deliceo, E., Birgen, N., Pelit, N.B., Cuhadaroglu, C., Kocagoz, A.S., Ovali, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
First Clinical Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476504/
https://www.ncbi.nlm.nih.gov/pubmed/32922804
http://dx.doi.org/10.1016/j.nmni.2020.100756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476504/
https://www.ncbi.nlm.nih.gov/pubmed/32922804
http://dx.doi.org/10.1016/j.nmni.2020.100756

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