SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis

SIRT7 is a member of the mammalian sirtuins and functions as an NAD(+)-dependent deacylase. Here we show that SIRT7 deficiency leads to a lowered histone acetyltransferase 1 (HAT1) activity and therefore decreased histone H4K5 and H4K12 acetylation. This in turn causes CENP-A dislocation at the cent...

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Detalles Bibliográficos
Autores principales: Liu, Xiyang, Li, Chengling, Li, Qing, Chang, Hung-Chun, Tang, Yun-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476862/
https://www.ncbi.nlm.nih.gov/pubmed/32861997
http://dx.doi.org/10.1016/j.isci.2020.101461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476862/
https://www.ncbi.nlm.nih.gov/pubmed/32861997
http://dx.doi.org/10.1016/j.isci.2020.101461

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