Knockout of vascular smooth muscle EGF receptor in a mouse model prevents obesity-induced vascular dysfunction and renal damage in vivo

AIMS/HYPOTHESIS: Obesity causes type 2 diabetes leading to vascular dysfunction and finally renal end-organ damage. Vascular smooth muscle (VSM) EGF receptor (EGFR) modulates vascular wall homeostasis in part via serum response factor (SRF), a major regulator of VSM differentiation and a sensor for...

Descripción completa

Detalles Bibliográficos
Autores principales: Stern, Christian, Schreier, Barbara, Nolze, Alexander, Rabe, Sindy, Mildenberger, Sigrid, Gekle, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476975/
https://www.ncbi.nlm.nih.gov/pubmed/32548701
http://dx.doi.org/10.1007/s00125-020-05187-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476975/
https://www.ncbi.nlm.nih.gov/pubmed/32548701
http://dx.doi.org/10.1007/s00125-020-05187-4

Ejemplares similares